Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease

Turk J Med Sci. 2019 Feb 11;49(1):139-146. doi: 10.3906/sag-1804-169.

Abstract

Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease.

Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery.

YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = –0.674 and r = –0.471, respectively).

This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements

Keywords: YKL-40; CKD; hemodialysis; atherosclerosis; endothelial dysfunction.

MeSH terms

  • Adult
  • Biomarkers / blood
  • Chitinase-3-Like Protein 1 / blood*
  • Correlation of Data
  • Disease Progression
  • Endothelium, Vascular* / metabolism
  • Endothelium, Vascular* / physiopathology
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Middle Aged
  • Patient Acuity
  • Renal Dialysis / methods*
  • Renal Insufficiency, Chronic* / blood
  • Renal Insufficiency, Chronic* / diagnosis
  • Renal Insufficiency, Chronic* / physiopathology
  • Renal Insufficiency, Chronic* / therapy
  • Reproducibility of Results
  • Vasodilation*

Substances

  • Biomarkers
  • CHI3L1 protein, human
  • Chitinase-3-Like Protein 1