Nanotechnology is one of the hot topics not only in pharmaceutical industry, but also in many others that are currently existing in our daily lives. Since the last two decades, many nanotechnology based drugs have been introduced in the market providing new and optimized treatment perspectives. In addition to that, local regulatory authorities also meet new challenging issues regarding the development process of the nanopharmaceuticals. It is a clear fact that the novelty of nanopharmaceuticals also include a more precise clarification process on the efficacy and safety of the formulations for the benefit of public health. Therefore, current scientific improvements as well as current regulatory perspectives are reflected in this review.