Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism

Aging Male. 2020 Dec;23(5):669-678. doi: 10.1080/13685538.2019.1573220. Epub 2019 Feb 15.


Hypogonadism affects an extensive part of the male population, especially among the elderly. The quest for treatment regarding low levels of serum testosterone and male infertility has, therefore, worldwide relevance. Zinc has important biological actions insofar as the male reproductive physiology and endocrine system. In general, a common and safe recommendation for zinc in the treatment of male hypogonadism is 220 mg of zinc sulfate (equivalent to 50 mg of elemental zinc) twice a day, over one to four months. Additionally, it may be further required to extend, both the treatment, dose and daily fractionation of this mineral. Albeit medicinal doses of zinc may increase total testosterone and improve sperm count, the current body of evidence does not suggest broad recommendations regarding the use of zinc for all types of hypogonadism. In many cases, the use of zinc supplements is insufficient, with the use of surgery and drugs being required for an effective treatment.

Keywords: Hypogonadism; ZMA; seminogram; testosterone; zinc.

MeSH terms

  • Aged
  • Humans
  • Hypogonadism* / drug therapy
  • Infertility, Male* / drug therapy
  • Male
  • Pharmaceutical Preparations*
  • Testosterone
  • Zinc


  • Pharmaceutical Preparations
  • Testosterone
  • Zinc