Molecular mechanism of interactions between chrysin and I-kappa-B kinase epsilon (IKKe)/tank binding kinase-1(TBK1): Cell-based assay and in silico molecular docking studies

J Biomol Struct Dyn. 2020 Feb;38(2):589-596. doi: 10.1080/07391102.2019.1581086. Epub 2019 Mar 26.

Abstract

Communicated by Ramaswamy H. Sarma.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalytic Domain
  • Cell Line, Tumor
  • Cytokines / metabolism
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology
  • Humans
  • I-kappa B Kinase / chemistry*
  • Mice
  • Molecular Docking Simulation*
  • Oxygen Consumption / drug effects
  • Protein Binding / drug effects
  • Protein Serine-Threonine Kinases / metabolism*
  • RAW 264.7 Cells
  • Signal Transduction / drug effects
  • Thermodynamics

Substances

  • Cytokines
  • Flavonoids
  • chrysin
  • Protein Serine-Threonine Kinases
  • TBK1 protein, human
  • I-kappa B Kinase