Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma

Ophthalmic Surg Lasers Imaging Retina. 2019 Feb 1;50(2):e1-e9. doi: 10.3928/23258160-20190129-12.


Background and objective: To identify the clinical and imaging characteristics of isolated retinal astrocytic hamartomas (IRAH).

Patients and methods: A case series of eight patients diagnosed with IRAH.

Results: The average age at diagnosis was 32 years (range: 9 years to 80 years). After a median follow-up time of 59 months, none of the lesions had demonstrated any change or growth. Fundus fluorescein angiogram identified hyperfluorescence in five of six imaged lesions. Fundus autofluorescence (FAF) changes were seen in all eight cases. Ocular ultrasound was able to identify a lesion in only five of the seven cases. Optical coherence tomography (OCT) was able to document the tumor thickness and level of retinal invasion in all cases.

Conclusions: Multimodal imaging is useful for the diagnosis and monitoring of IRAH. OCT and FAF are sensitivity tools for identifying IRA and can be used to follow the thickness and margins of these lesions. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e1-e9.].

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged, 80 and over
  • Astrocytes / pathology
  • Child
  • Diagnostic Techniques, Ophthalmological*
  • Female
  • Fluorescein Angiography / methods
  • Fundus Oculi
  • Hamartoma / diagnostic imaging*
  • Hamartoma / pathology
  • Humans
  • Male
  • Middle Aged
  • Multimodal Imaging / methods*
  • Optical Imaging / methods*
  • Retinal Neoplasms / diagnostic imaging*
  • Retinal Neoplasms / pathology
  • Sensitivity and Specificity
  • Ultrasonography
  • Young Adult