Recent Advances in Clathrin-Independent Endocytosis

F1000Res. 2019 Jan 31;8:F1000 Faculty Rev-138. doi: 10.12688/f1000research.16549.1. eCollection 2019.


Endocytic pathways are broadly classified into clathrin dependent and independent on the basis of the requirement for the coat protein, clathrin. The molecular pathways and mechanisms underlying the formation of clathrin-independent pathways are still being explored, and this review summarizes recent advances and emerging functional roles of these diverse pathways. In particular, this review will discuss the growing consensus on the role of BAR domain proteins and the actin machinery in different clathrin-independent pathways and its significance to the functions fulfilled by these endocytic pathways.

Keywords: BAR domain; Clathrin-independent; actin-dependent; endocytosis.

Publication types

  • Review

MeSH terms

  • Actins
  • Clathrin* / physiology
  • Endocytosis* / physiology
  • Metabolic Networks and Pathways


  • Actins
  • Clathrin

Grant support

The author(s) declared that no grants were involved in supporting this work.