Endogenous multidien rhythm of epilepsy in rats

Exp Neurol. 2019 May:315:82-87. doi: 10.1016/j.expneurol.2019.02.006. Epub 2019 Feb 15.


Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal. Here, we analyzed chronic EEG data (>30 days) in male epileptic rats and unraveled not only circadian but also, slower, multidien rhythms of interictal epileptiform activity with periodicity of about 2-3 and 5-7 days. Importantly, seizures were not uniformly distributed over time, but rather clustered at preferential phases of these underlying rhythms, delineating critical circadian times and multidien phase of heightened seizure risk. Multidien rhythms were not synchronous across animals or with human intervention suggesting an endogenous generator. In epilepsy, across species, unknown factors modulate seizure timing in cyclical patterns over multiple days.

Keywords: Chronic EEG; Chronobiology; Circadian; Epilepsy; Multidien.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Circadian Rhythm
  • Electroencephalography
  • Environment
  • Epilepsy, Temporal Lobe / physiopathology*
  • Male
  • Periodicity*
  • Rats
  • Rats, Sprague-Dawley
  • Seizures / physiopathology