Trichosordarin A, a norditerpene glycoside from the marine-derived fungus Trichoderma harzianum R5

Nat Prod Res. 2020 Jul;34(14):2037-2042. doi: 10.1080/14786419.2019.1574782. Epub 2019 Feb 19.


A new sordarin derivative, trichosordarin A (1), with a unique norditerpene aglycone was isolated from the culture of a marine-sediment-derived fungal strain, Trichoderma harzianum R5. Its structure and relative configuration were unequivocally identified by a combination of 1D/2D NMR, IR, and mass spectrometric methods. Compound 1 was assayed to be toxic to the marine zooplankton Artemia salina.

Keywords: Trichoderma harzianum; norditerpene; trichosordarin A.

MeSH terms

  • Animals
  • Artemia / drug effects
  • Molecular Conformation
  • Molecular Structure
  • Spectrum Analysis
  • Trichoderma / chemistry*