The role of progesterone elevation in IVF

Reprod Biol. 2019 Mar;19(1):1-5. doi: 10.1016/j.repbio.2019.02.003. Epub 2019 Feb 15.


Elevation of progesterone during the late follicular phase of stimulated in-vitro fertilization cycles is a frequent event, which negatively impacts the outcome. Over the years evidence has demonstrated a direct relationship between late-follicular elevated progesterone and endometrial receptivity. In this regard, elective cryopreservation of all good quality embryos and transfer in a subsequent frozen/thawed cycle is the most common strategy adopted by clinicians in case of elevated progesterone. Nonetheless, recent evidence suggests that elective cryopreservation might not entirely resolve the reduced pregnancy outcomes associated with the elevation of progesterone, considering that the increase may affect not only implantation, but also embryo quality.

Keywords: Embryo quality; Endometrial receptivity; Implantation; In vitro fertilization; Progesterone elevation.

Publication types

  • Review

MeSH terms

  • Cryopreservation
  • Embryo, Mammalian
  • Female
  • Fertilization in Vitro*
  • Humans
  • Pregnancy
  • Pregnancy Outcome
  • Progesterone / blood*


  • Progesterone