Modelling diabetic vasculopathy with human vessel organoids

Ryuji Morizane

doi:10.1038/s41581-019-0125-8

Modelling diabetic vasculopathy with human vessel organoids

Nat Rev Nephrol. 2019 May;15(5):258-260. doi: 10.1038/s41581-019-0125-8.

Author

Ryuji Morizane^{1

2

3

4}

Affiliations

¹ Renal Division, Brigham and Women's Hospital, Boston, MA, USA. morizanr@da2.so-net.ne.jp.
² Department of Medicine, Harvard Medical School, Boston, MA, USA. morizanr@da2.so-net.ne.jp.
³ Harvard Stem Cell Institute, Cambridge, MA, USA. morizanr@da2.so-net.ne.jp.
⁴ Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA. morizanr@da2.so-net.ne.jp.

Abstract

A new study reports that human blood vessel organoids can be generated through the directed differentiation of human pluripotent stem cells. Use of these blood vessel organoids to model diabetic vasculopathy led to the identification of a new potential therapeutic target, suggesting this system could have translational value for studies of diabetes complications.

Publication types

Comment

MeSH terms

Diabetes Mellitus
Diabetic Angiopathies*
Humans
Organoids
Pluripotent Stem Cells*

Abstract

Publication types

MeSH terms

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