Effectiveness of Long-acting Trimetazidine in Different Clinical Situations in Patients with Stable Angina Pectoris: Findings from ODA Trial

Maria G Glezer; Vladimir A Vygodin; ODA investigators

doi:10.1007/s40119-019-0128-3

Effectiveness of Long-acting Trimetazidine in Different Clinical Situations in Patients with Stable Angina Pectoris: Findings from ODA Trial

Cardiol Ther. 2019 Jun;8(1):69-78. doi: 10.1007/s40119-019-0128-3. Epub 2019 Feb 18.

Authors

Maria G Glezer¹, Vladimir A Vygodin²; ODA investigators

Collaborators

ODA investigators:
E L Nekrasova, I A Khlopina, K S Nubret, Y A Agafonova, S P Ternavsky, O V Bardukova, N M Kutyakova, Y V Berestennikova, V V Ustyugova, T A Filatova, I G Khalturina, K A Ishchenko, O A Karutskaja, V I Panikar, O A Bolkhovitina, E I Bondarev, I N Eremin, S I Kadashova, O M Frolova, I L Petukhova, A V Suvorov, Y V Zhuchkova, M A Kuhl, L V Rodionova, T P Musurok, I A Ivkova, A S Ermakov, E M Stukalova, V N Chumakov, E Y Rubezhanskaja, A A Kotlova, A V Pushkareva, L V Dmitrieva, E V Bel'kina, O E Solov'eva, S L Panyulaytenene, O G Sarkisyan, G V Konovalova, S S Kuznetsova, S V Nikolaeva, I V Trubitsyna, O A Alekseeva, M E Kozmina, N A Babautseva, I V Kochetkova, A A Anokhin, E V Vovk, A N Buyko, E S Malahatka, M A Iskra, S N Shilonosov, G V Moiseenko, Y S Tomm, N A Stopyatuk, E G Grigorieva, A A Zaitseva, N A Zaitseva, I A Sirotkina, R L Kiyanichenko, S P Grigoriev, N V Medvedeva, M Y Svatkov, L V Golubeva, L A Kozhevnikova, A A Chernova, A Y Dolbilkin, A Y Palvinskaya, T V Baranova, T S Habeeva, D A Khodus, G N Ermolaeva, I V Arbatskaja, V R Idiatullina, M E Egorova, I R Galimova, M V Kuklina, A A Mamatadzhiev, R N Rahmatullina, Z F Kim, V S Stepanova, I E Gerr, G I Levchenko, S E Dubinkina, R A Zoob, O N Krokhmal, S V Lisina, N G Kudryavtseva, D V Sitnikov, D G Lunegov, N A Evdokimova, I V Ivanova, A V Manilova, O L Bessergeneva, E E Mokhova, O V Kulchytska, O V Shulikina, V G Ananenko, O T Ivanova, M D Alentyeva, M E Didur, K A Zemzyulina, N P Kartina, I A Kapustina, N N Skurikhina, G I Novoselova, T A Gracheva, I V Shiryaev, O V Avdeeva, O S Fedorova, E A Filatkina, N V Pankova, A V Mikhailova, T V Samoilenko, N V Zhurkina, E N Riazantseva, L V Mokrousova, A Z Kulieva, T N Rychkova, T A Skripka, S Y Krasnevich, L F Fedorova, S A Abdalova, M S Tremaskina, Z N Mushaeva, T A Sladkova, P S Gabisova, T V Kononova, V V Maslova, A N Kazakova, E O Khamitsaeva, O S Ratnikova, N A Ivanova, E V Savel'eva, I V Obikhodova, G I Puakseva, A A Gunin, I Y Skvortsova, I I Chugunova, N A Shestopalova, O A Kutina, Y V Ponomareva, T P Nikolina, S I Sokolova, T N Fastovshchuk, L I Pak, A S Kazaryan, O V Sabitova, T V Kuznetsova, Z K Kudzaeva, A A Pomiluyko, A V Kudryavtsev, T M Gabaraeva, E A Titova, E A Levtsova, N I Faiman, V V Chernomorets, O A Evseeva, N S Lopata, L A Lobankova, O V Komarova, E M Tsybulnikova, O A Kutz, O S Kalimeeva, I G Nudikova, M V Chibrikina, K A Sarkisova, R V Kalakova, N V Erezeeva, G S Shirganova, A A Chmil, M S Kafanova, S V Ermolaeva, R A Koshrokova, G M Orozalieva, E S Barnashova, S V Akhadov, E V Podmoskova, A B Borisova, E V Chirkunova, T A Chernova, N V Kosova, O V Guseva, S A Kuzovkova, I V Mulin, O V Larina, S V Mingaleva, L A Tsvetkova, I K Vysotskaja, T Y Degtereva, L I Reshetova, I I Koblyakova, A N Chigisova, L A Krivenko, M A Matveeva, L A Kozlova, O O Yakhontova, G R Musina, E A Kuznetsova, V I Adamov, S P Podolnaya, A V Mukhin, I A Giley, N M Savelyeva, A V Novikova, Y N Makhonina, T S Shemetova, L V Tarasova, I V Galushko, L I Nasakina, M I Chaadaeva, O A Grechishkina, G A Hamrina, O V Oshchepkova, S D Senina, E B Graf, I M Kozhevnikova, S F Lukina, E V Vinokurova, A T Sobol, N K Nevolina, O T Zdankovich, Z N Luzhnova, A A Mamedova, V A Osipova, V L Zheltova, L N Shahramanyan, E D Bulygina, N N Panchenko, T P Tolstokoneva, G V Batalo, M K Mazrukho, S A Chepurnenko, N I Alexandrova, N N Starostina, I S Grushetskaya, O Y Novikova, O A Krylova, L V Arhipova, S V Kostomarova, O V Khudyakova, M A Nasyrova, N N Yakimova, G V Kositsyna, E A Ovchinnikova, E I Ryazanova, V P Kuzmin, A D Basharin, L V Bulycheva, A R Soesheva, G R Timaeva, N K Burenina, N I Nikolov, I V Udaltsova, Z M Zhenihova, E S Pukhova, E A Shmeleva, A I Luchko, A M Ermolenko, E Y Melekhova, Y V Kadyseva, E V Nechvolod, E M Al-Atar, E J Sereda, N A Grigorieva, V G Algina, A E Borisov, Z S Sabolova, Z S Novozhenina, L A Silantyeva, N N Litsis, N V Gamayunova, E E Velikanova, N Y Gulyaeva, O A Zhuravleva, E G Chichvarina, E G Kalinina, O S Bidzhieva, N V Vasilieva, N V Novokreschenova, G R Osmanova, S L Lugovtsova, E N Gadomskaya, E A Pastukhova, L V Krapivina, I B Kireeva, E E B Mironova, O G Nikiforova, A E Vorfolomeeva, E I Orekhova, O K Evdokimova, E A Naumova, A V Shtets, M V Novikova, L F Moiseeva, O I Larina, V N Trusilkina, E A Arinushkina, P V Manokhin, T A Sotnikova, M P Khazova, E P Gubareva, Y I Gladysheva, M D Khalikova, O S Bochkareva, O V Andreeva, N V Dmitrieva, M P Maklakova, L A Kapustina, I Y Kuzmina, A A Mzhelskaya, L P Demenko, K I Yunusova, Y V Strunevskaya, O M Tkacheva, L Y Dehont, Y I Kulikova, T A Nadtochiy, G Z Harrasova, U R Ueldanov, Y N Akhmametyeva, E A Badykova, D R Zainitdinova, T R Timerbulatov, L M Zaerova, A M Nurlygayanova, A G Vardikyan, M V Zhukova, E G Zhuravleva, E N Sabanina, T N Pogodina, N A Cherepanova, L V Zakhezina, V G Petrovф, I V Charykova, V A Chinkova, A A Kuritsyna, A A Kos'kina

Affiliations

¹ Department of Preventive and Emergency Cardiology, Sechenov First Moscow State Medical University, Moscow, Russia. 287ast@mail.ru.
² Laboratory of Biostatistics, National Medical Research Center for Preventive Medicine of the Ministry of Healthcare, Moscow, Russia.

Abstract

Introduction: Trimetazidine (TMZ) has been shown to be efficacious for angina treatment. The TMZ 80-mg formulation allows one-daily (od) dosage, which could improve symptom control and adherence.

Methods: The 3-month, observational, multicenter, prospective ODA (antianginal effectiveness and tolerability of trimetazidine modified release 80 mg Once Daily in stable Angina patients in real-world practice) study assessed TMZ 80 mg od effectiveness in stable angina patients with persistent symptoms despite therapy. Two clinical situations were compared: patients who initiated treatment with TMZ 80 mg od (initiation group) and patients who were previously treated with TMZ 20 mg thrice daily (tid) or TMZ 35 mg MR twice daily (bid) and switched to TMZ 80 mg od (switch group). Number of angina attacks, short-acting nitrate (SAN) consumption, self-reported patient daily activity, Canadian Cardiovascular Society (CCS) class, adherence to antianginal therapy, overall efficacy and tolerability were assessed.

Results: A significant decrease in weekly number of angina attacks was observed for both the initiation group (n = 1841 patients) from 4.8 ± 3.5 at baseline to 0.9 ± 1.4 at 3 months (M3) (P < 0.001), and the switch group (n = 1216 patients) from 4.4 ± 1.3 at baseline to 0.9 ± 1.3 at M3 (P < 0.001). Significant reduction in SAN consumption and improvement in CCS class were observed for both groups. Adherence to antianginal therapy improved in both groups at 1 month (M1) and M3. Overall effectiveness of TMZ 80 mg od was rated by physicians as "very good" (68% initiation group, 70% switch group), "good" (31% initiation group, 29% switch group), "moderate" (1%, both groups) or "poor" (< 1%, both groups). Overall tolerability of TMZ 80 mg od was rated by physicians as "very good" (75%), "good" (25%) or "moderate" (< 1%) in both groups.

Conclusions: TMZ 80 mg od, in association with other antianginal therapy, effectively reduced angina attacks and SAN consumption and improved physical activity and adherence to antianginal therapy both in patients initiating TMZ treatment and those switching from a bid or tid formulation.

Trial registration: ISRCTN registry Identifier, ISRCTN97780949.

Funding: Servier. Plain language summary available for this article.

Keywords: Cardiology; Observational study; Real-world evidence; Stable angina; Trimetazidine.