B Vitamins and Ageing

Subcell Biochem. 2018:90:451-470. doi: 10.1007/978-981-13-2835-0_15.


Vitamin B contributes to the overall health and wellbeing, including that of energy metabolism, methylation, synthesis and DNA repair and proper immune function. Deficiency in B vitamins has been linked to neurocognitive disorders, mitochondrial dysfunction, immune dysfunction and inflammatory conditions. In ageing populations B vitamin deficiency has been linked to cardiovascular disorders, cognitive dysfunction, osteoporosis and methylation disorders and can increase the risk of developing degenerative diseases, particularly cardiovascular disease, cognitive diseases and osteoporosis. Optimization of B vitamin status in the elderly may prove beneficial in the prevention of degenerative diseases. Here we discuss broadly the role of B vitamins in ageing.

Keywords: Ageing; Cobalamin; Folate; Niacin; Pyridoxine; Riboflavin; Thiamine; Vitamin B.

Publication types

  • Review

MeSH terms

  • Aging / metabolism*
  • Aging / pathology
  • Humans
  • Vitamin B Complex / metabolism*
  • Vitamin B Complex / therapeutic use
  • Vitamin B Deficiency / complications
  • Vitamin B Deficiency / diet therapy


  • Vitamin B Complex