Borderline Brenner Tumor: A Review of the Literature

Arch Pathol Lab Med. 2019 Oct;143(10):1278-1280. doi: 10.5858/arpa.2018-0285-RS. Epub 2019 Feb 19.


Brenner tumors arise from ovarian epithelium, accounting for approximately 5% of benign ovarian epithelial tumors. The World Health Organization classification groups them into benign, borderline, and malignant on the basis of proliferation and invasiveness, and borderline Brenner tumor is defined as "displaying epithelial proliferation beyond that seen in benign Brenner's tumor, but lacking stromal invasion." Borderline Brenner tumors are rare. Fewer than 60 cases have been reported. The more recent articles mostly focus on pathogenesis. We reviewed the literature on borderline Brenner tumor and have summarized the clinical and pathologic findings, as well as the treatment, differential diagnoses, and recent advances in histogenesis and molecular pathogenesis.

Publication types

  • Review

MeSH terms

  • Brenner Tumor / diagnosis
  • Brenner Tumor / genetics
  • Brenner Tumor / pathology*
  • Brenner Tumor / therapy
  • Diagnosis, Differential
  • Epithelium / pathology
  • Female
  • Humans
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / therapy
  • Ovary / pathology