Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis

Xu Zhang; Takayuki Fujii; Hidenori Ogata; Ryo Yamasaki; Katsuhisa Masaki; Yiwen Cui; Takuya Matsushita; Noriko Isobe; Jun-Ichi Kira

doi:10.1016/j.jneuroim.2019.01.010

Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis

J Neuroimmunol. 2019 May 15:330:38-43. doi: 10.1016/j.jneuroim.2019.01.010. Epub 2019 Feb 13.

Authors

Xu Zhang¹, Takayuki Fujii², Hidenori Ogata³, Ryo Yamasaki⁴, Katsuhisa Masaki⁵, Yiwen Cui⁶, Takuya Matsushita⁷, Noriko Isobe⁸, Jun-Ichi Kira⁹

Affiliations

¹ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China. Electronic address: shu-@neuro.med.kyushu-u.ac.jp.
² Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: takayuki@neuro.med.kyushu-u.ac.jp.
³ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: hidenori@neuro.med.kyushu-u.ac.jp.
⁴ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: ryoya@neuro.med.kyushu-u.ac.jp.
⁵ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
⁶ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: cuiyiwen@med.kyushu-u.ac.jp.
⁷ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: matusita@neuro.med.kyushu-u.ac.jp.
⁸ Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: kuroki@neuro.med.kyushu-u.ac.jp.
⁹ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: kira@neuro.med.kyushu-u.ac.jp.

PMID: 30784775
DOI: 10.1016/j.jneuroim.2019.01.010

Abstract

Hypertrophic pachymeningitis (HP) is a rare neurologic disease causing inflammatory fibrous thickening of the brain and spinal dura mater. We investigated the cerebrospinal fluid cytokine profile of HP by measuring 28 cytokines/chemokines/growth factors with a multiplexed fluorescent immunoassay in 8 patients with HP (6 idiopathic, 1 IgG4-related, 1 anti-neutrophil cytoplasmic antibody-related), and 11 with other non-inflammatory neurologic diseases (OND). Interleukin (IL)-4, IL-5, IL-9, IL-10, TNF-α, and CXCL8/IL-8 levels were significantly higher in idiopathic HP (IHP) than OND. Cluster analyses disclosed two major clusters: one mainly consisted of IHP and the other of OND, suggesting a unique cytokine profile in IHP.

Keywords: Cerebrospinal fluid; Cytokine; Hypertrophic pachymeningitis; Type 2 helper T cell.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers / blood
Biomarkers / cerebrospinal fluid
Chemokines / blood
Chemokines / cerebrospinal fluid*
Cytokines / blood
Cytokines / cerebrospinal fluid*
Female
Humans
Intercellular Signaling Peptides and Proteins / blood
Intercellular Signaling Peptides and Proteins / cerebrospinal fluid*
Male
Meningitis / blood
Meningitis / cerebrospinal fluid*
Meningitis / diagnosis*
Middle Aged
Th2 Cells / metabolism

Substances

Biomarkers
Chemokines
Cytokines
Intercellular Signaling Peptides and Proteins