Markers of neuroinflammation influence measures of cortical thickness in bipolar depression

Psychiatry Res Neuroimaging. 2019 Mar 30;285:64-66. doi: 10.1016/j.pscychresns.2019.01.009. Epub 2019 Jan 29.


We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.

Keywords: Cytokines; Depression; Emotional processing.

MeSH terms

  • Adult
  • Biomarkers / metabolism
  • Bipolar Disorder / diagnostic imaging*
  • Bipolar Disorder / metabolism*
  • Bipolar Disorder / psychology
  • Decision Making / physiology
  • Female
  • Gyrus Cinguli / diagnostic imaging*
  • Gyrus Cinguli / metabolism*
  • Humans
  • Inflammation Mediators / metabolism*
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Organ Size / physiology
  • Young Adult


  • Biomarkers
  • Inflammation Mediators