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Review
. Jan-Feb 2019;9(1):10-20.

Effects of L-citrulline Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis

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Free PMC article
Review

Effects of L-citrulline Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis

Bahareh Barkhidarian et al. Avicenna J Phytomed. .
Free PMC article

Abstract

Objective: We aimed to conduct a systematic review and meta-analysis of clinical trials that examined the effects of L-citrulline supplementation on blood pressure (BP).

Materials and methods: We searched MEDLINE, SCOPUS, PUBMED and Google scholar databases from inception to November 16, 2017 and 811 papers were identified, of which 8 trials with 10 data sets met the inclusion criteria. Inclusion criteria were: (1) application of randomized clinical trial with either crossover or parallel designs; (2) studies conducted in adults (≥18 y); (3) oral supplementation with L-citrulline compared to control group; (4) expression of sufficient data about systolic and diastolic BP at baseline and at the end of the study in each group. BP effects were pooled by random-effects models, with trials weighted by inverse variance.

Results: The included studies' sample size ranged between 12 and 34 subjects. The mean age of the participants in these trials ranged between 22 and 71 years. Dosage of L-citrulline supplementation varied from 3 to 9 g/day. Duration of the intervention ranged between 1 and 17 weeks. The pooled changes in systolic and diastolic BP were (MD, -4.10 mm Hg; 95% CI [-7.94, -0.26]; p=0.037) and (MD -2.08 mm Hg; 95% CI [-4.32, 0.16]; P=0.069), respectively. The subgroup analysis showed a significant diastolic BP reduction in studies that used doses of ≥6 g/day (MD -2.75 mm Hg; 95% CI [-5.37, -0.12]; p=0.04).

Conclusion: Our results suggest that L-citrulline supplementation may reduce systolic BP. A significant reduction in diastolic BP was observed only in the studies that used doses ≥ 6 g/day.

Keywords: Blood pressure; L-citrulline; Supplementation.

Figures

Figure 1
Figure 1
Flow chart of study selection
Figure 2
Figure 2
Forest plot of WMD of SBP (A) and DBP (B) at baseline and after L-citrulline supplementation and their 95% confidence intervals
Figure 3
Figure 3
Funnel plot for SBP (A) and DBP (B).

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