The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells

Front Oncol. 2019 Feb 6;9:40. doi: 10.3389/fonc.2019.00040. eCollection 2019.


Cancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, double blind phase 2 clinical trial.

Keywords: CXCL8; CXCR1; breast cancer; cancer stem-like cells; reparixin.

Publication types

  • Review