Effect of Antiobiotic-Induced Disbiosis and Its Correction with Probiotics on Myocardial Tolerance to Ischemia-Reperfusion Injury in SPF Rats

Bull Exp Biol Med. 2019 Feb;166(4):440-443. doi: 10.1007/s10517-019-04368-5. Epub 2019 Feb 20.


Changes in morphofunctional parameters of the isolated heart subjected to global ischemia-reperfusion were studied in SPF Wistar rats with antibiotic-induced dysbiosis (AID) treated with lyophilized yeast Saccharomyces boulardii and inactivated probiotic bacteria Lactobacillus reuteri KR2017. In contrast to S. boulardii, correction of dysbiosis with L. reuteri KR2017 against the background of gastric hypersecretion and standard antimicrobial therapy led to an increase in fat content and a decrease in free and bound water in tissues and to a significant reduction in myocardial infarct size caused by ischemia/ reperfusion injury.

Keywords: antibiotic-induced disbiosis; infarct size; ischemia; isolated heart; probiotics.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / adverse effects*
  • Dysbiosis / chemically induced*
  • Dysbiosis / drug therapy*
  • Limosilactobacillus reuteri / physiology
  • Male
  • Myocardial Reperfusion Injury / drug therapy*
  • Myocardial Reperfusion Injury / microbiology
  • Myocardium / metabolism
  • Probiotics / therapeutic use*
  • Rats
  • Rats, Wistar
  • Saccharomyces boulardii / physiology


  • Anti-Bacterial Agents