Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation

Bull Exp Biol Med. 2019 Feb;166(4):466-468. doi: 10.1007/s10517-019-04373-8. Epub 2019 Feb 20.


Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity. The possible mitogenic action of Noopept was estimated by its effect on cell proliferation. Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study. These data suggest that Noopept does not stimulate cell growth.

Keywords: Ki-67; Noopept; Pro-Gly substituted dipeptides; cell cycle; proliferation.

MeSH terms

  • Cell Cycle / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Dipeptides / chemistry
  • Dipeptides / pharmacology
  • Flow Cytometry
  • HEK293 Cells
  • Humans
  • Ki-67 Antigen / metabolism
  • Neuroprotective Agents / pharmacology*
  • Peptides / chemistry
  • Peptides / pharmacology


  • Dipeptides
  • Ki-67 Antigen
  • Neuroprotective Agents
  • Peptides
  • prolylglycine
  • ethyl phenylacetyl-Pro-Gly