Neutralizing Antibody against Enterovirus D68 in Children and Adults before 2014 Outbreak, Kansas City, Missouri, USA1

Emerg Infect Dis. 2019 Mar;25(3):585-588. doi: 10.3201/eid2503.180960.

Abstract

We evaluated enterovirus D68 seroprevalence in Kansas City, Missouri, USA, from samples obtained during 2012-2013. Neutralizing antibodies against Fermon and the dominant 2014 Missouri isolate were universally detected. Titers increased with age. Widespread circulation of enterovirus D68 occurred before the 2014 outbreak. Research is needed to determine a surrogate of protection.

Keywords: 14-18949; 14-18952; 14-18953; EV-D68; Fermon; Hispanic; Kansas City; Missouri; United States; adults; age; children; enterovirus; microneutralization; neutralizing antibody; outbreak; race/ethnicity; respiratory infections; seroprevalence; viruses.

Publication types

  • Historical Article

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Neutralizing / immunology*
  • Antibodies, Viral / immunology*
  • Child
  • Child, Preschool
  • Disease Outbreaks*
  • Enterovirus D, Human / classification
  • Enterovirus D, Human / genetics
  • Enterovirus D, Human / immunology*
  • Enterovirus Infections / epidemiology*
  • Enterovirus Infections / history
  • Enterovirus Infections / immunology*
  • Enterovirus Infections / virology
  • Female
  • History, 21st Century
  • Humans
  • Male
  • Middle Aged
  • Missouri / epidemiology
  • Phylogeny
  • Seroepidemiologic Studies
  • Young Adult

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral