MIG in Cutaneous Systemic Lupus Erythematosus

Clin Ter. Jan-Feb 2019;170(1):e71-e76. doi: 10.7417/CT.2019.2111.

Abstract

Many studies reported that monokine induced by interferon (IFN)-γ(MIG), and its receptor chemokine (C-X-C motif) receptor (CXCR)3, are expressed by T cells in different types of cutaneous damages associated with lupus, and that the CXCR3-activating chemokines are produced locally, suggesting that they play a significant role in the recruitment of T cells in these inflammatory lesions. Circulating MIG levels are increased in cutaneous Systemic Lupus Erythematosus (SLE) patients and strongly correlated with the disease activity. The data discussed in this review show that there is an increasing evidence that MIG may participate in the pathogenesis of a variety of the manifestations of cutaneous SLE, even if the exact role of MIG in the pathogenesis of this disease remains to be clarified.

Keywords: Cutaneous Systemic Lupus Erythematosus; MIG.

Publication types

  • Review

MeSH terms

  • Chemokine CXCL9 / metabolism*
  • Humans
  • Lupus Erythematosus, Systemic / pathology*
  • Male
  • Receptors, CXCR3 / metabolism*
  • T-Lymphocytes / metabolism

Substances

  • CXCR3 protein, human
  • Chemokine CXCL9
  • Receptors, CXCR3