Enhancement of Retinal Function and of Neural Conduction Along the Visual Pathway Induced by Treatment with Citicoline Eye Drops in Liposomal Formulation in Open Angle Glaucoma: A Pilot Electrofunctional Study

Adv Ther. 2019 Apr;36(4):987-996. doi: 10.1007/s12325-019-0897-z. Epub 2019 Feb 21.


Introduction: To evaluate the retinal function and the relative neural conduction along the visual pathway after treatment with citicoline in liposomal formulation (CLF) eye drops in patients with open angle glaucoma (OAG).

Methods: Twelve OAG patients (mean age ± standard deviation 52.58 ± 11.39 years, intraocular pressure < 18 mmHg under topical hypotensive treatment, Humphrey field analyzer mean deviation - 4.49 ± 2.46 dB) were enrolled. Only one eye of studied patients was treated with CLF eye drops (OMK1-LF®, Omikron Italia, 3 drops/day) (CLF group, 12 eyes) over a period of 4 months. In CLF eyes, pattern electroretinogram (PERG), visual evoked potentials (VEP), and visual field test were assessed at baseline and at the end of treatment (month 4).

Results: After treatment with CLF eye drops, a significant increase of PERG P50-N95 amplitude and a significant shortening of VEP P100 implicit time were found. In CLF eyes, the shortening of VEP P100 implicit time was significantly correlated with the increase of PERG P50-N95 amplitude.

Conclusion: Data from this pilot study suggest that treatment with CLF eye drops induces an enhancement of the retinal bioelectrical responses (increase of PERG amplitude) with a consequent improvement of the bioelectrical activity of the visual cortex (shortening of VEP implicit time).

Funding: Omikron Italia S.r.l. and Opko Health Europe.

Keywords: Citicoline; Glaucoma; Ophthalmology; PERG; VEP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Availability
  • Cytidine Diphosphate Choline* / administration & dosage
  • Cytidine Diphosphate Choline* / pharmacokinetics
  • Drug Monitoring
  • Electroretinography / methods
  • Evoked Potentials, Visual*
  • Female
  • Glaucoma, Open-Angle* / diagnosis
  • Glaucoma, Open-Angle* / drug therapy
  • Humans
  • Liposomes
  • Male
  • Middle Aged
  • Neural Conduction / drug effects
  • Ophthalmic Solutions / administration & dosage
  • Ophthalmic Solutions / pharmacokinetics
  • Pilot Projects
  • Retina / drug effects
  • Retina / physiopathology
  • Tonometry, Ocular / methods
  • Visual Field Tests / methods
  • Visual Pathways / drug effects


  • Liposomes
  • Ophthalmic Solutions
  • Cytidine Diphosphate Choline

Associated data

  • figshare/10.6084/m9.figshare.7655411