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. 2019 Apr;8(4):1652-1654.
doi: 10.1002/cam4.2011. Epub 2019 Feb 21.

Human Cancer, the Naked Mole Rat and Faunal Turnovers

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Free PMC article

Human Cancer, the Naked Mole Rat and Faunal Turnovers

Anders Bredberg et al. Cancer Med. .
Free PMC article

Abstract

We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in 'living fossil' animals may help us find tools for cancer prevention and treatment.

Keywords: Heterocephalus glaber; Cretaceous-Paleogene boundary; Peto's paradox; cancer resistance; human cancer excess; human mutation rate; naked mole rat; rapid human evolution.

Conflict of interest statement

There is no conflict of interest.

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