The glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation

J Allergy Clin Immunol. 2019 Jun;143(6):2299-2302.e3. doi: 10.1016/j.jaci.2019.02.006. Epub 2019 Feb 18.

Abstract

A 2-hour exposure to 500 μg/m3 wood smoke particles caused neutrophilic airway inflammation in human volunteers, with GSTM1 null genotype being associated with greater inflammatory response to this pollutant.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Air Pollutants / adverse effects*
  • Female
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Inflammation / chemically induced
  • Male
  • Neutrophils / immunology
  • Smoke / adverse effects*
  • Sputum / immunology
  • Wood
  • Young Adult

Substances

  • Air Pollutants
  • Smoke
  • Glutathione Transferase
  • glutathione S-transferase M1