Early use of PEPA dialyzer for light chains removal and for the recovery from myeloma cast nephropathy: A case report

Gabriele Donati; Fulvia Zappulo; Anna Laura Croci Chiocchini; Giorgia Comai; Elena Zamagni; Gaetano La Manna

doi:10.1111/hdi.12733

Early use of PEPA dialyzer for light chains removal and for the recovery from myeloma cast nephropathy: A case report

Hemodial Int. 2019 Jul;23(3):E97-E99. doi: 10.1111/hdi.12733. Epub 2019 Feb 21.

Authors

Gabriele Donati¹, Fulvia Zappulo¹, Anna Laura Croci Chiocchini¹, Giorgia Comai¹, Elena Zamagni², Gaetano La Manna¹

Affiliations

¹ Nephrology Dialysis and Renal Transplantation Unit, L. & A. Seràgnoli, S.Orsola University Hospital, Bologna, Italy.
² Hematology and Oncology Unit, L. & A. Seràgnoli, S.Orsola University Hospital, Bologna, Italy.

PMID: 30791209
DOI: 10.1111/hdi.12733

Abstract

Chemotherapy and extracorporeal treatment reduce serum free light chains (FLCs) allowing the recovery of acute kidney injury (AKI) caused by myeloma cast nephropathy (MCN). We report the first case of recovery from AKI in a patient with MCN who underwent the removal of FLCs using the PEPA filter, with an undisclosed cut-off, combined with chemotherapy for multiple myeloma (MM).

Keywords: Bortezomib; Multiple myeloma; PEPA (Poly Ester Polymer Alloy); cast nephropathy; dialysis; free light chains.

Publication types

Case Reports

MeSH terms

Acute Kidney Injury / pathology
Acute Kidney Injury / therapy*
Humans
Immunoglobulin Light Chains / isolation & purification*
Male
Middle Aged
Multiple Myeloma / pathology
Multiple Myeloma / therapy*
Renal Dialysis / instrumentation
Renal Dialysis / methods*
Treatment Outcome

Substances

Immunoglobulin Light Chains