Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

Int J Mol Sci. 2019 Feb 20;20(4):925. doi: 10.3390/ijms20040925.

Abstract

Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review.

Keywords: cancer; chemoresistance; metastasis; resveratrol; tumor microenvironment.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Biomarkers
  • Dietary Supplements*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / etiology
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Neovascularization, Pathologic / drug therapy
  • Resveratrol / chemistry
  • Resveratrol / pharmacology
  • Resveratrol / therapeutic use*
  • Signal Transduction / drug effects
  • Stress, Physiological / drug effects
  • Tumor Microenvironment / drug effects*

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents, Phytogenic
  • Biomarkers
  • Resveratrol