Prucalopride for the treatment of constipation: a view from 2015 and beyond

Expert Rev Gastroenterol Hepatol. 2019 Mar;13(3):257-262. doi: 10.1080/17474124.2019.1568238. Epub 2019 Jan 23.


Prucalopride is a prokinetic drug, that has been commercially available in recent years for the treatment of chronically constipated patients. In this update of a previous 2016 article, we reviewed the more recent data supporting its role in the treatment of constipation and constipation-associated conditions. Areas covered: We carried out an extensive literature review on the effects of prucalopride for the years 2012-2018 by means of scientific databases and manual research. More evidence was found on its possible therapeutic role in conditions in which constipation plays a role as an associated symptom, such as opioid-induced constipation, constipation-predominant irritable bowel syndrome, post-operative ileus, colonic diverticular disease, drug-related constipation, and chronic intestinal pseudo-obstruction. Expert opinion: Based on the added literature evidence, we feel that prucalopride is an effective, although expensive, drug for the treatment of primary and secondary forms of constipation, and of other clinical conditions associated with constipation.

Keywords: Chronic constipation; laxatives; prucalopride; treatment.

Publication types

  • Review

MeSH terms

  • Benzofurans / adverse effects
  • Benzofurans / economics
  • Benzofurans / therapeutic use*
  • Constipation / diagnosis
  • Constipation / drug therapy*
  • Constipation / economics
  • Constipation / physiopathology
  • Cost-Benefit Analysis
  • Defecation / drug effects*
  • Drug Costs
  • Gastrointestinal Motility / drug effects*
  • Humans
  • Intestines / drug effects*
  • Intestines / physiopathology
  • Laxatives / adverse effects
  • Laxatives / economics
  • Laxatives / therapeutic use*
  • Recovery of Function
  • Serotonin 5-HT4 Receptor Agonists / adverse effects
  • Serotonin 5-HT4 Receptor Agonists / economics
  • Serotonin 5-HT4 Receptor Agonists / therapeutic use*
  • Treatment Outcome


  • Benzofurans
  • Laxatives
  • Serotonin 5-HT4 Receptor Agonists
  • prucalopride