Sex-specific pheromone responses in Caenorhabditis elegans

EMBO Rep. 2019 Mar;20(3):e47599. doi: 10.15252/embr.201847599. Epub 2019 Feb 21.


The characterization of receptors for sex pheromones provides important clues for understanding the mechanisms controlling animal mating and reproduction. In this issue, Wan et al 1 identify a putative sex pheromone receptor, the G protein‐coupled receptor SRD‐1, acting in a single Caenorhabditis elegans olfactory neuron class, called AWA, to mediate male attraction to volatile sex pheromones. Like in other systems, C. elegans sex pheromone elicits sex‐specific responses even though sex pheromone activates sensory neurons of both sexes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins*
  • Female
  • Male
  • Neurons
  • Pheromones
  • Sex Attractants*


  • Caenorhabditis elegans Proteins
  • Pheromones
  • Sex Attractants