The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

Hypertens Pregnancy. 2019 May;38(2):65-72. doi: 10.1080/10641955.2019.1581215. Epub 2019 Feb 22.


Objective: The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia.

Methods: Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model.

Results: The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006).

Conclusion: The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease.

Keywords: Melatonin; meta-analysis; pathogenesis; preeclampsia; pregnancy.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Female
  • Humans
  • Melatonin / blood*
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / etiology
  • Pregnancy


  • Melatonin