Cognitive neuropsychiatric analysis of an additional large Capgras delusion case series

Cogn Neuropsychiatry. 2019 Mar;24(2):123-134. doi: 10.1080/13546805.2019.1584098. Epub 2019 Feb 22.

Abstract

Introduction: Although important to cognitive neuropsychiatry and theories of delusions, Capgras delusion has largely been reported in single case studies. Bell et al. [2017. Uncovering Capgras delusion using a large scale medical records database. British Journal of Psychiatry Open, 3(4), 179-185] previously deployed computational and clinical case identification on a large-scale medical records database to report a case series of 84 individuals with Capgras delusion. We replicated this approach on a new database from a different mental health service provider while additionally examining instances of violence, given previous claims that Capgras is a forensic risk.

Methods: We identified 34 additional cases of Capgras. Delusion phenomenology, clinical characteristics, and presence of lesions detected by neuroimaging were extracted.

Results: Although most cases involved misidentification of family members or partners, a notable minority (20.6%) included the misidentification of others. Capgras typically did not present as a monothematic delusion. Few cases had identifiable lesions with no evidence of right-hemisphere bias. There was no evidence of physical violence associated with Capgras.

Conclusions: Findings closely replicate Bell et al. (2017). The majority of Capgras delusion phenomenology conforms to the "dual route" model although a significant minority of cases cannot be explained by this framework.

Keywords: Delusional misidentification; forensic; neuropsychiatry; psychosis; schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Capgras Syndrome / diagnostic imaging*
  • Capgras Syndrome / psychology*
  • Cognition / physiology
  • Delusions / diagnostic imaging*
  • Delusions / psychology*
  • Family / psychology
  • Female
  • Humans
  • Middle Aged
  • Neuroimaging / methods
  • Neuropsychological Tests*
  • Violence / psychology
  • Young Adult