Dissecting Cell Lineages: From Microscope to Kaleidoscope

Cell. 2019 Feb 21;176(5):949-951. doi: 10.1016/j.cell.2019.01.054.


Single-cell transcriptomics coupled with dynamic two-color fluorescence are used by Gehart et al. (2019) to elucidate adult mammalian cell trajectories in real time. The authors' close examination of intestinal enteroendocrine differentiation reveals new lineage features and shifting cell identities, and experiments in organoids uncover specific roles for transcriptional regulators identified by this approach.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Intestines
  • Organoids*
  • Stem Cells*