Spatial and Temporal Locomotor Learning in Mouse Cerebellum

Neuron. 2019 Apr 3;102(1):217-231.e4. doi: 10.1016/j.neuron.2019.01.038. Epub 2019 Feb 19.


Stable and efficient locomotion requires the precise coordination of movement across the limbs and body. Learned changes in interlimb coordination can be induced by exposure to a split-belt treadmill that imposes different speeds under each side of the body. Here, we demonstrate locomotor learning on a split-belt treadmill in mice. Mouse locomotor adaptation is specific to measures of interlimb coordination, has spatial and temporal components that adapt at different rates, and is context specific. The many similarities between human and mouse locomotor adaptation suggest that this form of locomotor learning is highly conserved across vertebrates. Using a variety of approaches, we demonstrate that split-belt adaptation in mice specifically depends on the intermediate cerebellum but is insensitive to large lesions of the cerebral cortex. Finally, cell-type-specific chemogenetics combined with quantitative behavioral analysis reveals that spatial and temporal components of locomotor adaptation are dissociable on the circuit level. VIDEO ABSTRACT.

Publication types

  • Research Support, Non-U.S. Gov't
  • Video-Audio Media

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Ataxia / physiopathology
  • Cerebellum / physiology*
  • Cerebral Cortex / physiology
  • Gait / physiology*
  • Gait Analysis
  • Locomotion / physiology*
  • Mice
  • Mice, Inbred Strains
  • Mice, Neurologic Mutants
  • Purkinje Cells / physiology
  • Sensorimotor Cortex / physiology*
  • Spatial Learning / physiology*
  • Time Factors