Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta

Calcif Tissue Int. 1986 Jan;38(1):16-20. doi: 10.1007/BF02556589.


Noncollagenous proteins and proteoglycan from the bone and dentin of affected and normal half-siblings neonatal calves with the Australian variant of bovine osteogenesis imperfecta (BOI-A) were quantitated. In contrast to a clinically similar syndrome of BOI in the progeny of a second progenitor bull identified in Texas (BOI-T), osteonectin and bone sialoprotein levels were normal in the affected BOI-A bone, and dentin phosphophoryn levels were normal in affected BOI-A teeth. However, bone proteoglycan in the affected BOI-A calves was depleted to one-third of the level found in normal siblings, a finding qualitatively similar to the depletion of bone proteoglycan in the BOI-T syndrome. These results suggest that quantitation of noncollagenous proteins and proteoglycans may be a useful technique for differentiating clinically similar syndromes of OI in man.

MeSH terms

  • Animals
  • Australia
  • Bone and Bones / analysis*
  • Carrier Proteins / analysis
  • Cattle
  • Cattle Diseases / metabolism*
  • Chromatography, DEAE-Cellulose
  • Dentin / analysis*
  • Disease Models, Animal
  • Electrophoresis, Polyacrylamide Gel
  • Enzyme-Linked Immunosorbent Assay
  • Minerals / analysis
  • Osteogenesis Imperfecta / metabolism
  • Osteogenesis Imperfecta / veterinary*
  • Osteonectin
  • Phosphoproteins / analysis
  • Proteins / analysis*
  • Proteoglycans / analysis


  • Carrier Proteins
  • Minerals
  • Osteonectin
  • Phosphoproteins
  • Proteins
  • Proteoglycans
  • phosphophoryn