Metabolic and neurobehavioral response following intraovarian administration of autologous activated platelet rich plasma: First qualitative data

Neuro Endocrinol Lett. 2019 Jan;39(6):427-433.


Objectives: This work assessed sexual and neurobehavioral parameters after ovarian treatment with autologous PRP.

Design: Questionnaire study.

Material and methods: Patients receiving ovarian PRP injection (n=80) due to low ovarian reserve and/or at least 1 prior failed IVF cycle were sampled. Pre- and post-treatment levels in self-reported daily energy, sleep quality, skin tone/hair thickness/nail growth, cognitive clarity, menstrual pattern, cervical mucus/vaginal lubrication, libido, sexual activity, ability to achieve orgasm, and overall sexual experience were measured.

Results: Mean±SD age and baseline BMI among patients were 45.5±6yrs and 25±5.1kg/m2, respectively. Average weight loss after ovarian PRP was 1kg (p=0.056). After ovarian PRP, superior nail growth, skin tone, and hair thickness was observed by 46.3% of patients [95%CI=35%,57.8%]; the same ratio experienced increased "clarity of thinking" following the procedure. Irregular or absent menses affected 56.3% of patients at enrollment, and menses returned or cyclicity improved in 24.4% after treatment [95%CI=12.9%,39.5%]. Increased post-treatment vaginal lubrication/cervical mucus production was reported by 51.3% of women [95%CI=39.8%, 62.6%] accompanied by increased libido in 55% [95%CI=43.5%,66.2%]. More frequent sexual activity after ovarian PRP was noted from 46.3% of subjects [95%CI=35%, 57.8%] coinciding with a 45% improvement in overall sexual experience before vs. after ovarian PRP [95%CI=33.9%, 56.5%].

Conclusion: This investigation is the first to document responses across neurobehavioral and metabolic parameters after ovarian PRP. Injection of PRP-derived growth factors directly into ovarian tissue seems to enable a local signaling milieu favoring development of hormonally active ovarian elements, thus "re-potentiating" low or absent reserve.

MeSH terms

  • Adult
  • Female
  • Humans
  • Intercellular Signaling Peptides and Proteins / administration & dosage*
  • Middle Aged
  • Ovarian Reserve / drug effects*
  • Platelet-Rich Plasma*
  • Regenerative Medicine / methods*
  • Reproductive Physiological Phenomena / drug effects
  • Retrospective Studies


  • Intercellular Signaling Peptides and Proteins