Eye organogenesis: A hierarchical view of ocular development

Curr Top Dev Biol. 2019;132:351-393. doi: 10.1016/bs.ctdb.2018.12.008. Epub 2019 Jan 3.

Abstract

This chapter provides an overview of the early developmental origins of six ocular tissues: the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of these tissue types are concurrently specified and undergo a complex set of morphogenetic movements that facilitate their structural interconnection. Within the context of vertebrate eye organogenesis, we also discuss the genetic hierarchies of transcription factors and signaling pathways that regulate growth, patterning, cell type specification and differentiation.

Keywords: Ciliary body; Cornea; Iris; Lens; Ocular development; Retina; Retinal pigmented epithelium.

Publication types

  • Review

MeSH terms

  • Animals
  • Ciliary Body / embryology
  • Ciliary Body / growth & development
  • Ciliary Body / metabolism
  • Cornea / embryology
  • Cornea / growth & development
  • Cornea / metabolism
  • Eye / embryology
  • Eye / growth & development
  • Eye / metabolism*
  • Gene Expression Regulation, Developmental*
  • Humans
  • Lens, Crystalline / embryology
  • Lens, Crystalline / growth & development
  • Lens, Crystalline / metabolism
  • Organogenesis / genetics*
  • Retina / embryology
  • Retina / growth & development
  • Retina / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism

Substances

  • Transcription Factors