As a natural extract from turmeric, curcumin has extensive pharmacological effects, such as anti-tumor, anti-inflammation, anti-oxidative stress, anti-microbial, immunoregulation and so on. In recent years, an increasing number of basic and clinical researches have shown that curcumin takes therapeutic effects on various diseases, such as gastrointestinal diseases, cardiovascular diseases, autoimmune diseases, neuropsychiatric diseases and so on. Many of the pharmacological effects and mechanisms of curcumin are associated with protective effects of intestinal mucosal barrier. It can protect intestinal mucosal barrier through mutiple pathways, including anti-inflammation, anti-oxidative stress, anti-bacterial, anti-apoptosis, regulating intestinal microecology and intestinal immune response and so on. This paper summarizes the protective effects of curcumin on intestinal barrier function and the mechanism, in order to provide new ideas for diagnosis and treatment of intestinal dysfunction.
姜黄素作为一种源于姜黄的天然提取物质，具有抗肿瘤、抗炎、抗氧化应激、抗微生物、调节免疫等多方面药理作用。近年来越来越多的基础及临床研究证明姜黄素对多种疾病具有治疗作用，如胃肠道疾病、心血管疾病、自身免疫性疾病、神经精神性疾病等。姜黄素的诸多药理作用及机制均与肠黏膜屏障功能保护相关，它可通过抗炎、抗氧化应激、抗菌、调节肠道微生态和肠道免疫反应、抗凋亡等多种途径保护肠黏膜屏障。本文综述姜黄素对肠黏膜屏障功能的保护作用及其机制，为肠功能障碍的诊治提供新思路。.
Keywords: Curcumin; Gastrointestinal tract; Intestinal mucosal barrier.