Electrical synapses regulate both subthreshold integration and population activity of principal cells in response to transient inputs within canonical feedforward circuits

PLoS Comput Biol. 2019 Feb 25;15(2):e1006440. doi: 10.1371/journal.pcbi.1006440. eCollection 2019 Feb.

Abstract

As information about the world traverses the brain, the signals exchanged between neurons are passed and modulated by synapses, or specialized contacts between neurons. While neurotransmitter-based synapses tend to exert either excitatory or inhibitory pulses of influence on the postsynaptic neuron, electrical synapses, composed of plaques of gap junction channels, continuously transmit signals that can either excite or inhibit a coupled neighbor. A growing body of evidence indicates that electrical synapses, similar to their chemical counterparts, are modified in strength during physiological neuronal activity. The synchronizing role of electrical synapses in neuronal oscillations has been well established, but their impact on transient signal processing in the brain is much less understood. Here we constructed computational models based on the canonical feedforward neuronal circuit and included electrical synapses between inhibitory interneurons. We provided discrete closely-timed inputs to the circuits, and characterize the influence of electrical synapse strength on both subthreshold summation and spike trains in the output neuron. Our simulations highlight the diverse and powerful roles that electrical synapses play even in simple circuits. Because these canonical circuits are represented widely throughout the brain, we expect that these are general principles for the influence of electrical synapses on transient signal processing across the brain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Brain / physiology
  • Computational Biology / methods*
  • Computer Simulation
  • Connexins
  • Electrical Synapses / physiology*
  • Gap Junctions / physiology
  • Interneurons / physiology
  • Ion Channels
  • Neural Inhibition
  • Neurons / physiology*
  • Neurotransmitter Agents
  • Synapses / physiology

Substances

  • Connexins
  • Ion Channels
  • Neurotransmitter Agents

Grant support

NSF IOS 1557474 (JSH), Whitehall Foundation (JSH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.