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, 244 (8), 702-708

Human-relevant Preclinical in Vitro Models for Studying Hepatobiliary Development and Liver Diseases Using Induced Pluripotent Stem Cells

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Human-relevant Preclinical in Vitro Models for Studying Hepatobiliary Development and Liver Diseases Using Induced Pluripotent Stem Cells

Pooja Chaudhari et al. Exp Biol Med (Maywood).

Abstract

In this review, we address the potential of human-induced pluripotent stem cell-based hepatobiliary differentiation technology as a means to study human liver development and cell fate determination, and to model liver diseases in an effort to develop a new human-relevant preclinical platform for drug development.

Keywords: Human-induced pluripotent stem cell; YAP; hepatobiliary development; liver disease.

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