Myeloid neoplasm with eosinophilia and PCM1-JAK2 associated with acute promyelocytic leukemia with PML-RARA

Leuk Lymphoma. 2019 Sep;60(9):2299-2303. doi: 10.1080/10428194.2019.1581927. Epub 2019 Feb 26.

Authors

Sajad Salehi¹, John M Astle², Sam Sadigh³, Jonathan Lake³, Vania Aikawa³, Guilin Tang⁴, Sa A Wang⁴, Adam Bagg³

Affiliations

¹ Department of Pathology, St. John Hospital and Medical Center , Detroit , MI , USA.
² Department of Pathology, Medical College of Wisconsin , Milwaukee , WI , USA.
³ Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania , Philadelphia , PA , USA.
⁴ Department of Hematopathology, University of Texas MD Anderson Cancer Center , Houston , TX , USA.

PMID: 30806106
DOI: 10.1080/10428194.2019.1581927

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Aged, 80 and over
Biopsy, Large-Core Needle
Bone Marrow / pathology
Cytogenetic Analysis
Eosinophilia / diagnosis*
Eosinophilia / drug therapy
Eosinophilia / genetics
Eosinophilia / pathology
Fatal Outcome
Female
Gene Rearrangement
Humans
Leukemia, Promyelocytic, Acute / diagnosis*
Leukemia, Promyelocytic, Acute / drug therapy
Leukemia, Promyelocytic, Acute / genetics
Leukemia, Promyelocytic, Acute / pathology
Myeloproliferative Disorders / diagnosis*
Myeloproliferative Disorders / drug therapy
Myeloproliferative Disorders / genetics
Myeloproliferative Disorders / pathology
Neoplasms, Multiple Primary / diagnosis*
Neoplasms, Multiple Primary / drug therapy
Neoplasms, Multiple Primary / genetics
Neoplasms, Multiple Primary / pathology
Oncogene Proteins, Fusion / genetics*

Substances

Oncogene Proteins, Fusion
PCM1-JAK2 fusion protein, human
promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein

Supplementary concepts

Myeloproliferative Disorder, Chronic, with Eosinophilia