Changes in serum miRNA-let-7 level in children with attention deficit hyperactivity disorder treated by repetitive transcranial magnetic stimulation or atomoxetine: An exploratory trial

Pengfei Cao; Linxiao Wang; Qi Cheng; Xiaojing Sun; Qi Kang; Libin Dai; Xianju Zhou; Zixiang Song

doi:10.1016/j.psychres.2019.02.037

Changes in serum miRNA-let-7 level in children with attention deficit hyperactivity disorder treated by repetitive transcranial magnetic stimulation or atomoxetine: An exploratory trial

Psychiatry Res. 2019 Apr:274:189-194. doi: 10.1016/j.psychres.2019.02.037. Epub 2019 Feb 17.

Authors

Pengfei Cao¹, Linxiao Wang², Qi Cheng³, Xiaojing Sun³, Qi Kang³, Libin Dai³, Xianju Zhou⁴, Zixiang Song⁵

Affiliations

¹ Psychological Centre for Adolescents and Children, The Affiliated 102th Hospital of the Second Military Medical University of Chinese People's Liberation Army, Changzhou, China; Department of Political Affairs, College of Politics, National Defense University of Chinese People's Liberation Army, Shanghai, China.
² Laboratory of Neurological Diseases, Department of Neurology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China.
³ Psychological Centre for Adolescents and Children, The Affiliated 102th Hospital of the Second Military Medical University of Chinese People's Liberation Army, Changzhou, China.
⁴ Laboratory of Neurological Diseases, Department of Neurology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China; Department of Neurology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. Electronic address: xianju_zhou@yahoo.com.
⁵ Psychological Centre for Adolescents and Children, The Affiliated 102th Hospital of the Second Military Medical University of Chinese People's Liberation Army, Changzhou, China. Electronic address: axiang952@sohu.com.

PMID: 30807970
DOI: 10.1016/j.psychres.2019.02.037

Abstract

We aimed to investigate whether microRNA-let-7d (miRNA-let-7d) and miRNA-107 may serve as diagnostic and therapeutic biomarkers of attention deficit hyperactivity disorder (ADHD). The relative expression level of miRNA-let-7d and miRNA-107 in patients with ADHD and in a healthy control group was detected by real-time polymerase chain reaction. The blood samples were collected at 6 weeks after repetitive transcranial magnetic stimulation (rTMS) or atomoxetine (ATX) in ADHD patients, and the relative expression levels of the two miRNAs before and after treatments were compared. There were significant differences in the expression level of miRNA-let-7d between ADHD patients and healthy children, as well as before and after rTMS or ATX treatment in ADHD patients. However, the expression of miRNA-107 showed no significant difference between ADHD patients and healthy children or before and after rTMS (or ATX treatment). These results suggest that serum miRNA-let-7d may serve as a potential diagnostic and therapeutic biomarker for children with ADHD.

Keywords: Atomoxetine; Attention deficit hyperactivity disorder; Repetitive transcranial magnetic stimulation; miRNA-107; miRNA-let-7d.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adrenergic Uptake Inhibitors / therapeutic use*
Atomoxetine Hydrochloride / therapeutic use*
Attention Deficit Disorder with Hyperactivity / blood*
Attention Deficit Disorder with Hyperactivity / therapy
Biomarkers / blood
Child
Double-Blind Method
Female
Humans
Male
MicroRNAs / blood*
Transcranial Magnetic Stimulation / methods*
Treatment Outcome

Substances

Adrenergic Uptake Inhibitors
Biomarkers
MicroRNAs
mirnlet7 microRNA, human
Atomoxetine Hydrochloride