New Hope in Prostate Cancer Precision Medicine? miRNA Replacement and Epigenetics

Clin Cancer Res. 2019 May 1;25(9):2679-2681. doi: 10.1158/1078-0432.CCR-19-0061. Epub 2019 Feb 26.

Abstract

SPINK1 +/ETS - prostate cancer is an aggressive disease with poor clinical outcome. New data suggest a novel treatment by upregulating the expression of miR-338-5p/-421 through epigenetic modulation or by miRNA replacement. This is a new and interesting concept that warrants further exploration in clinical trials.See related article by Bhatia et al., p. 2755.

Publication types

  • Comment

MeSH terms

  • Epigenesis, Genetic
  • Humans
  • Male
  • MicroRNAs / genetics*
  • Precision Medicine
  • Prostatic Neoplasms / genetics*
  • Trypsin Inhibitor, Kazal Pancreatic / genetics

Substances

  • MicroRNAs
  • SPINK1 protein, human
  • Trypsin Inhibitor, Kazal Pancreatic