Antimicrobial Photodynamic Therapy: An Effective Alternative Approach to Control Bacterial Infections

Hassan Mahmoudi; Abbas Bahador; Maryam Pourhajibagher; Mohammad Yousef Alikhani

doi:10.15171/jlms.2018.29

Antimicrobial Photodynamic Therapy: An Effective Alternative Approach to Control Bacterial Infections

J Lasers Med Sci. 2018 Summer;9(3):154-160. doi: 10.15171/jlms.2018.29. Epub 2018 Jul 28.

Authors

Hassan Mahmoudi¹, Abbas Bahador², Maryam Pourhajibagher³, Mohammad Yousef Alikhani¹

Affiliations

¹ Microbiology Department, Hamadan University of Medical Sciences, Hamadan, Iran.
² Microbiology Department, Tehran University of Medical Sciences, Tehran, Iran.
³ Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Introduction: The purpose of this review was to evaluate the available literature for in vitro and in vivo effectiveness of antimicrobial Photodynamic therapy (aPDT) in the field of bacteriology. Methods: A review of the relevant articles carried out in PubMed and Scopus to determine the efficiency of aPDT used in the reduction of microbial infection. Thirty-one relevant documents retrieved from PubMed, Scopus by inserting "antimicrobial photodynamic therapy" and "bacterial infection" and "photodynamic therapy" keywords. Results: According to different results, aPDT can be used as an adjuvant for the treatment of infectious diseases. The use of photosensitizer methylene blue, toluidine blue O (TBO), indocyanine green with light diode laser centered at (630±10 nm) and (650±10 nm) wavelengths have been shown to have significant results for the treatment of infectious diseases and bactericidal properties Conclusion: These findings suggest that, aPDT can be an efficient method in the treatment of localized and superficial infections.

Keywords: Antimicrobial photodynamic therapy; Photosensitizer; Skin infections.

Publication types

Review