Spatial source phase: A new feature for identifying spatial differences based on complex-valued resting-state fMRI data

Hum Brain Mapp. 2019 Jun 15;40(9):2662-2676. doi: 10.1002/hbm.24551. Epub 2019 Feb 27.


Spatial source phase, the phase information of spatial maps extracted from functional magnetic resonance imaging (fMRI) data by data-driven methods such as independent component analysis (ICA), has rarely been studied. While the observed phase has been shown to convey unique brain information, the role of spatial source phase in representing the intrinsic activity of the brain is yet not clear. This study explores the spatial source phase for identifying spatial differences between patients with schizophrenia (SZs) and healthy controls (HCs) using complex-valued resting-state fMRI data from 82 individuals. ICA is first applied to preprocess fMRI data, and post-ICA phase de-ambiguity and denoising are then performed. The ability of spatial source phase to characterize spatial differences is examined by the homogeneity of variance test (voxel-wise F-test) with false discovery rate correction. Resampling techniques are performed to ensure that the observations are significant and reliable. We focus on two components of interest widely used in analyzing SZs, including the default mode network (DMN) and auditory cortex. Results show that the spatial source phase exhibits more significant variance changes and higher sensitivity to the spatial differences between SZs and HCs in the anterior areas of DMN and the left auditory cortex, compared to the magnitude of spatial activations. Our findings show that the spatial source phase can potentially serve as a new brain imaging biomarker and provide a novel perspective on differences in SZs compared to HCs, consistent with but extending previous work showing increased variability in patient data.

Keywords: auditory cortex; complex-valued fMRI data; default mode network; independent component analysis; resting-state fMRI data; schizophrenia; spatial source phase.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Auditory Cortex / diagnostic imaging
  • Auditory Cortex / physiology*
  • Auditory Cortex / physiopathology
  • Functional Neuroimaging / methods*
  • Functional Neuroimaging / standards
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Image Interpretation, Computer-Assisted / standards
  • Magnetic Resonance Imaging
  • Nerve Net / diagnostic imaging
  • Nerve Net / physiology*
  • Nerve Net / physiopathology
  • Reproducibility of Results
  • Schizophrenia / diagnostic imaging
  • Schizophrenia / physiopathology*