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Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology


Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology

Ning Qu et al. Int J Mol Sci.


Substantial improvements in cancer treatment have resulted in longer survival and increased quality of life in cancer survivors with minimized long-term toxicity. However, infertility and gonadal dysfunction continue to be recognized as adverse effects of anticancer therapy. In particular, alkylating agents and irradiation induce testicular damage that results in prolonged azoospermia. Although damage to and recovery of spermatogenesis after cancer treatment have been extensively studied, there is little information regarding the role of differences in testicular immunology in cancer treatment-induced male infertility. In this review, we briefly summarize available rodent and human data on immunological differences in chemotherapy or radiotherapy.

Keywords: azoospermia; cancer; male infertility; testicular immunology.

Conflict of interest statement

The authors declare no conflict of interest.


Figure 1
Figure 1
Immunological differences in the testes after cancer treatment.
Figure 2
Figure 2
Testes weights and epididymal spermatozoa numbers in normal and busulfan-/irradiation-treated mice.

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