Patient Perceptions of Antihypertensive Use as a Dementia Prevention Strategy: A Mixed-Method Analysis of a Web-Based Survey

J Alzheimers Dis. 2019;68(2):523-529. doi: 10.3233/JAD-181080.


We administered a mixed-method survey to 1,661 patients in a large health system to assess preferences toward antihypertensive use for dementia prevention. If a specific antihypertensive medication was shown to prevent or delay dementia, the vast majority (>90%) of respondents currently taking an antihypertensive reported that they would be willing to take that specific antihypertensive starting as early as mid-life. Concerns reported were potential side effects, lack of evidence of effectiveness, blood pressure being normal or low, and medication cost. Analysis of free-text responses revealed themes of concerns regarding evidence of effectiveness and health priorities.

Keywords: Alzheimer’s disease; antihypertensive agents; dementia; primary prevention.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / adverse effects
  • Antihypertensive Agents / economics
  • Antihypertensive Agents / therapeutic use*
  • Dementia / prevention & control*
  • Dementia / psychology*
  • Evidence-Based Medicine
  • Female
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Internet
  • Male
  • Middle Aged
  • Patient Satisfaction*
  • Perception
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult


  • Antihypertensive Agents