Tumour necrosis factor superfamily members in ischaemic vascular diseases

Cardiovasc Res. 2019 Mar 15;115(4):713-720. doi: 10.1093/cvr/cvz042.


Current treatment of ischaemic vascular diseases such as coronary and peripheral artery disease includes angioplasty and bypass grafting, as well as lipid lowering therapies and control of other cardiovascular risk factors. Numerous members of the tumour necrosis factor superfamily (TNFSF) have recently shown emerging roles in both the protection and progression of such diseases. Understanding the role TNFSF members play in ischaemic vascular disease may provide insight into the development of novel therapeutics to prevent or treat diseases relating to atherosclerosis and ischaemia. This review summarizes the most recent findings relating to TNFSF members and the mechanisms that precede ischaemic vascular disease progression, particularly endothelial dysfunction, chronic inflammation, and atherosclerotic plaque development. This review also explores recent translational research on the role of TNFSF therapies in cardiovascular disease.

Keywords: Atherosclerosis; Ischaemia; TNF superfamily.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteries / drug effects
  • Arteries / metabolism*
  • Arteries / pathology
  • Arteries / physiopathology
  • CD40 Ligand / metabolism
  • Cytokine TWEAK / metabolism
  • Humans
  • Ischemia / drug therapy
  • Ischemia / metabolism*
  • Ischemia / pathology
  • Ischemia / physiopathology
  • Receptors, Tumor Necrosis Factor / metabolism
  • Signal Transduction
  • TNF-Related Apoptosis-Inducing Ligand / metabolism
  • Tumor Necrosis Factor Inhibitors / therapeutic use
  • Tumor Necrosis Factor-alpha / metabolism
  • Tumor Necrosis Factors / metabolism*
  • Tumor Necrosis Factors / therapeutic use
  • Vascular Diseases / drug therapy
  • Vascular Diseases / metabolism*
  • Vascular Diseases / pathology
  • Vascular Diseases / physiopathology


  • Cytokine TWEAK
  • Receptors, Tumor Necrosis Factor
  • TNF protein, human
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human
  • TNFSF12 protein, human
  • Tumor Necrosis Factor Inhibitors
  • Tumor Necrosis Factor-alpha
  • Tumor Necrosis Factors
  • CD40 Ligand