Low mortality and short-term morbidity in very preterm infants in Austria 2011-2016

Abstract

Aim: The current study determined survival, short-term neonatal morbidity and predictors for death or adverse outcome of very preterm infants in Austria.

Methods: This population-based cohort study included 5197 very preterm infants (53.3% boys) born between 2011 and 2016 recruited from the Austrian Preterm Outcome Registry. Main outcome measures were gestational age-related mortality and major short-term morbidities.

Results: Overall, survival rate of all live-born infants included was 91.6% and ranged from 47.1% and 73.4% among those born at 23 and 24 weeks of gestation to 84.9% and 88.2% among infants born at 25 and 26 weeks to more than 90.0% among those with a gestational age of 27 weeks or more. The overall prevalence of chronic lung disease, necrotising enterocolitis requiring surgery, intraventricular haemorrhage Grades 3-4, and retinopathy of prematurity Grades 3-5 was 10.0%, 2.1%, 5.5%, and 3.6%, respectively. Low gestational age, low birth weight, missing or incomplete course of antenatal steroids, male sex, and multiple births were significant risk predictors for death or adverse short-term outcome.

Conclusion: In this national cohort study, overall survival rates were high and short-term morbidity rate was low.

Keywords: Preterm infants; Short-term outcome; Survival.