Mycobacterium tuberculosis infections in solid organ transplantation: Guidelines from the infectious diseases community of practice of the American Society of Transplantation

Clin Transplant. 2019 Sep;33(9):e13513. doi: 10.1111/ctr.13513. Epub 2019 Mar 22.

Abstract

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of tuberculosis in the pre- and post-transplant period. The challenges of screening for both latent and active TB in the setting of transplantation are reviewed. The use of interferon gamma release assays for detection of latent tuberculosis is discussed and compared to tuberculin skin testing. Given the limitations of both testing modality, it is important to consider exposure history and chest imaging. The clinical manifestations of active tuberculosis in transplantation are covered. New recommendations for treatment of latent tuberculosis and active tuberculosis are included.

Keywords: mycobacterial; mycobacterium; transplant; transplantation; tuberculosis.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Humans
  • Mycobacterium tuberculosis / isolation & purification*
  • Organ Transplantation / adverse effects*
  • Practice Guidelines as Topic / standards*
  • Societies, Medical
  • Transplant Recipients
  • Tuberculosis / diagnosis*
  • Tuberculosis / drug therapy*
  • Tuberculosis / etiology

Substances

  • Anti-Bacterial Agents