Transient Erythroblastopenia of Childhood: A Review for the Pediatric Emergency Medicine Physician

Pediatr Emerg Care. 2019 Mar;35(3):237-240. doi: 10.1097/PEC.0000000000001760.


Transient erythroblastopenia of childhood is a form of pure red cell aplasia that is self-limited and occurs in children 4 years old and younger. It is characterized by an absence or a significantly reduced quantity of erythroblasts in the bone marrow without underlying congenital red blood cell abnormalities. Transient erythroblastopenia of childhood should be considered in previously healthy children who present with normocytic anemia and lack of reticulocytosis without evidence of blood loss, hemolysis, or other causes of bone marrow suppression. Evaluation should be targeted at ruling out other causes of anemia. Management is mainly supportive, although some children may require blood transfusions for symptomatic anemia. Most patients demonstrate a return of hematopoiesis within two weeks of diagnosis and normalization of blood counts within two months.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anemia, Hemolytic, Congenital / diagnosis*
  • Anemia, Hemolytic, Congenital / therapy
  • Child, Preschool
  • Diagnosis, Differential
  • Erythrocyte Transfusion / methods
  • Female
  • Humans
  • Infant
  • Pediatric Emergency Medicine / methods*

Supplementary concepts

  • Transient erythroblastopenia of childhood