The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study

Pharmacol Rep. 2019 Apr;71(2):243-247. doi: 10.1016/j.pharep.2018.10.012. Epub 2018 Oct 24.


Background: Both selenium and vitamin D were found to reduce thyroid antibody titers in women with Hashimoto's thyroiditis.

Methods: The study enrolled 37 young drug-naïve euthyroid men with autoimmune thyroiditis, who were treated for 6 months with either exogenous vitamin D (group A, n = 20) or selenomethionine (group B, n = 17). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin and free thyroid hormones, serum levels of 25-hydroxyvitamin D, as well Jostel's thyrotropin, the SPINA-GT and the SPINA-GD indices were determined at the beginning and at the end of the study.

Results: At baseline, there were no differences between the study groups. Both vitamin D and selenomethionine reduced antibody titers and increased the SPINA-GT index. Only selenomethionine affected the SPINA-GD index, while only vitamin D increased 25-hydroxyvitamin D levels. Neither selenomethionine nor vitamin D significantly affected thyrotropin and free thyroid hormone levels. The effect of vitamin D on antibody titers correlated with baseline and treatment-induced changes in serum levels of 25-hydroxivitamin D.

Conclusions: Both vitamin D and selenomethionine have a beneficial effect on thyroid autoimmunity in drug-naïve men with Hashimoto's thyroiditis.

Keywords: Selenium; Thyroid autoimmunity; Thyroid function tests; Vitamin D.

MeSH terms

  • Adult
  • Autoantibodies / blood
  • Autoantigens / blood
  • Autoimmunity / immunology
  • Dietary Supplements
  • Hashimoto Disease / blood*
  • Hashimoto Disease / immunology
  • Humans
  • Hypothalamo-Hypophyseal System / metabolism
  • Iodide Peroxidase / blood
  • Iron-Binding Proteins / blood
  • Male
  • Pilot Projects
  • Pituitary Gland / metabolism
  • Selenomethionine / administration & dosage*
  • Selenomethionine / pharmacology
  • Thyroid Function Tests
  • Thyroid Hormones / blood*
  • Thyrotropin / blood
  • Vitamin D / administration & dosage*
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood


  • Autoantibodies
  • Autoantigens
  • Iron-Binding Proteins
  • Thyroid Hormones
  • anti-thyroglobulin
  • Vitamin D
  • Thyrotropin
  • Selenomethionine
  • 25-hydroxyvitamin D
  • TPO protein, human
  • Iodide Peroxidase